The evaluation of second line drug susceptibilities and molecular epidemiological profiles of multidrug resistance Mycobacterium tuberculosis isolates isoleted from different region of Turkey

Introduction: This study was planned to determine the second line drug resistance and molecular epidemiological profiles of multidrug resistant Mycobacterium tuberculosis isolates isolated from different geographical regions Turkey.
 Material Method: In our study, 63 MDR M. were evaluated for susceptibility sent laboratories Turkey. Secondary antituberculosis drugs by indirect proportion method. Epidemiological origins using IS6110-RFLP spoligotyping methods. 
 Results: Cycloserine, ethionamide, capreomycin, thiacetozone, ofloxacin, kanamsin paraaminosalicylic acid rates 15.87%, 19.04%, 7.93%, 6.34%, 11.11%, 12.69% 6.34.%, respectively. According results, 11 patterns obtained, including 52 consisting 5 clusters a single isolate. When we compared results with spoligotype database in world; 42 forming identified as predefined spoligotypes (LAM7-TUR, LAM9, T clade). 10 showed characteristics U family. Of that produced patterns, 8 Haarlem spoligotypes. It found 2 had Orphan 1 isolate BOV Conclusion: LAM7-TUR, clade families are common country world determined.